import os
import re
import smtplib
from email.mime.text import MIMEText
import time
import urllib.request

# Fill the next parameters

# SMTP server
smtp_server = "smtp.inbox.ru"
# SMTP port
smtp_port = 25
# SMTP login
smtp_address = "vatnika@inbox.ru"
# SMTP password
smtp_password = "35692858f"
# Email topic
email_topic = "Topic"
# Mail body
mail_body = "Spam message."
############################

usedEmails = []
num = 0

while True:
	u = urllib.request.urlopen("http://otvet.mail.ru/drama/")
	page = u.read()

	emailPattern = r"[0-9a-zA-Z_\-\.]+@[0-9a-z-A-Z\.]+\.[a-zA-Z]+"
	patternRe = re.compile(emailPattern)
	page=str(page)

	for address in patternRe.findall(page):
		if not address in usedEmails:
			num = num + 1
			msg = MIMEText(mail_body + address, "", "utf-8")
			msg['From'] = smtp_address
			msg['To'] = address
			msg['Subject'] = email_topic
			mailServer = smtplib.SMTP(smtp_server, smtp_port)
			mailServer.login(smtp_address, smtp_password)
			mailServer.sendmail(smtp_address, address, msg.as_string())
			mailServer.close()
			print(num, address)
			usedEmails.append(address)
			time.sleep(15)

Traceback (most recent call last):
  File "C:\py3eg\spamer.otvet.mail.ru.py", line 52, in <module>
    mailServer.sendmail(smtp_address, address, msg.as_string())
  File "C:\Python32\lib\smtplib.py", line 742, in sendmail
    raise SMTPDataError(code, resp)
smtplib.SMTPDataError: (550, b'Message was not accepted -- invalid mailbox.  Local mailbox xfb@Mail.Ru is unavailable: user not found')

try:
 {your code}
except Exception as e:
 print e

try:
 {your code}
except smtplib.SMTPDataError as e:
 print e

try:
 {your code}
except Exception as e:
 print e

(550, b'Message was not accepted -- invalid mailbox.  Local mailbox xfb@Mail.Ru is unavailable: user not found')
(550, b'Message was not accepted -- invalid mailbox.  Local mailbox xfb@Mail.Ru is unavailable: user not found')
(550, b'Message was not accepted -- invalid mailbox.  Local mailbox xfb@Mail.Ru is unavailable: user not found')
...

    try:
        mailServer.sendmail(smtp_address, address, msg.as_string())
    except smtplib.SMTPDataError as e:
        if e[0] == 550: # возможно, по-другому надо доставать, типа e.errno
            print('wrong address {0}'.format(address))
        continue