class Distr(models.Model):
    name          = models.CharField(max_length=20, verbose_name="Название")
    mail          = models.EmailField()
    file          = models.FileField(upload_to="csv", blank=True, verbose_name="Файл CSV")
    def save(self):
        super(Distr, self).save()
        csv_file   = self.file.path
        dataReader = csv.reader(open(csv_file), delimiter=',', lineterminator='\n')
        for row in dataReader:
            tovar  = Item()
            if row[0] != 'Бла-бла-бла':
                filter  = Item.objects.filter(distr = self, artikul = row[0])
                if filter:
                    exist = filter.get()
                    exist.price = row[2]
                    exist.count = row[3]
                    exist.save()
                else:
                    tovar.artikul = row[0]
                    tovar.name  = row[1]
                    tovar.distr = self
                    tovar.price = row[2]
                    tovar.count = row[3]
                    tovar.save()

dataReader = csv.reader(open(csv_file), delimiter=',', lineterminator='\n')

with open(csv_file, 'rb') as f:
    dataReader = csv.reader(f, delimiter=',', lineterminator='\n')

if row[0] != 'Бла-бла-бла':

from django.db import transaction
 
BULK_SAVE_COUNT = 500
 
class Distr(models.Model):
    ...
    @transaction.commit_manually
    def save(self):
        ...
        added_items = 0
        for row in dataReader:
            ...
            something.save()
            added_items += 1
            if not added_items % BULK_SAVE_COUNT:
                transaction.commit()
        transaction.commit()