a = 21220011333
a = list(str(a))
for i,x in enumerate(a):
     if x == '1':
            a[i] = '0'
     elif x == '0':
           a[i] = '1'
print(int(''.join(a)))

   
a = str(21220011333)
a = a.replace("0", "$").replace("1", "0").replace("$", "1")
print(int(a))

  
>>> n = '21220011333'
>>> d = {'0': '1', '1': '0'}
>>> out = ''.join(d.get(i, i) for i in n)
>>> out
'20221100333'
>>>