...
 * Serving Flask app "main" (lazy loading)
 * Environment: production
   WARNING: This is a development server. Do not use it in a production deployment.
   Use a production WSGI server instead.
 * Debug mode: off
 * Running on http://127.0.0.1:5000/ (Press CTRL+C to quit)
...

 <VirtualHost *:80>
   ServerAdmin webmaster@site
   ServerName  site
   WSGIScriptAlias / /var/www/domains/site/wsgi.py
    WSGIProcessGroup site
    WSGIScriptReloading On 
    WSGIPassAuthorization On
   <Directory "/var/www/domains/site/">
      Require all granted
   </Directory>
   <Directory "/var/www/domains/site/static/">
      Require all granted
   </Directory>
   Alias   /static    "/var/www/domains/site/static"
</VirtualHost>

  AH01276: Cannot serve directory /var/www/.../: No matching DirectoryIndex (index.html,index.html,index.html.var,index.php,index.phtml) found, and server-generated directory index forbidden by Options directive

 <VirtualHost 0.0.0.0:80>
    ServerName  site
    ServerAlias *.site
    CustomLog   /var/log/httpd/site.access_log combined
    ErrorLog    /var/log/httpd/site.error_log
    DocumentRoot    /var/www/domains/site
    WSGIDaemonProcess  user=umy group=mysite threads=5
    WSGIScriptAlias /site /var/www/domains/site/mysite.wsgi
    <Directory /var/www/domains/site>
        WSGIApplicationGroup %{GLOBAL}
        WSGIScriptReloading On
        Require all granted
    </Directory>
</VirtualHost>

 from moysite import app as application
import sys
sys.path.insert(0, '/var/www/domains/site/')
activate_this = '/var/www/domains/site/mysite/bin/activate_this.py'
execfile(activate_this, dict(__file__=activate_this))