Python-сообщество

 df = pd.DataFrame(columns=['сol_1','col_2','col_3','col_4'])
 data = [('str_1','str_2','str_3','str_4')]                        # именно так, а не иначе!!!

 df.loc[0]={'сol_1':'str_1','col_2':'str_2','col_3':'str_3','col_4':'str_4'}

 import pandas as pd
df = pd.DataFrame(columns=['col_1','col_2','col_3','col_4'])
data = [('str_1','str_2','str_3','str_4')] 
df.loc[0]={'сol_1':'str_1','col_2':'str_2','col_3':'str_3','col_4':'str_4'}
print(df)

  сol_1

 с