a = [1, 2, 3, 4, 5]
b = [1, 3]

 с = [2, 4, 5]

 c = list(set(a) - set(b))

  
>>> a = [1, 2, 3, 4, 5]
>>> b = [1, 3]
>>> 
>>> c = [i for i in a if i not in b]
>>> c
[2, 4, 5]
>>>