#!/usr/bin/env python
# -*- coding: utf-8 -*-

import sys
from PyQt4 import QtGui, QtCore

class MainAplication(QtGui.QWidget):
   
    def __init__(self, *args):
        QtGui.QWidget.__init__(self, *args)
        self.setWindowTitle(u"Title")
        self.setWindowIcon(QtGui.QIcon("logo.png"))
        
        mainLayout = QtGui.QGridLayout(self) 
        self.setLayout(mainLayout)

        startButton = QtGui.QPushButton(u"Пуск")
        
        mainLayout.addWidget(startButton, 0, 0)
                
    def sayHello(self):
        print "Hello Word"
        startButton.setDisabled(True)
        
        self.connect(startButton, QtCore.SIGNAL("clicked()"), self.sayHello())   
                
if __name__ == "__main__":
    app = QtGui.QApplication(sys.argv)
    aplica = MainAplication()
    aplica.show()
    sys.exit(app.exec_())

#!/usr/bin/env python
# -*- coding: utf-8 -*-

import sys
from PyQt4 import QtGui, QtCore

class MainAplication(QtGui.QWidget):
   
    def __init__(self, *args):
        QtGui.QWidget.__init__(self, *args)
        self.setWindowTitle(u"Title")
        self.setWindowIcon(QtGui.QIcon("logo.png"))
        
        mainLayout = QtGui.QGridLayout(self) 
        self.setLayout(mainLayout)

        self.startButton = QtGui.QPushButton(u"Пуск")
        
        mainLayout.addWidget(self.startButton, 0, 0)
        
        self.connect(self.startButton, QtCore.SIGNAL("clicked()"), self.sayHello)   
                
    def sayHello(self):
        print "Hello Word"
        self.startButton.setDisabled(True)
        
                       
if __name__ == "__main__":
    app = QtGui.QApplication(sys.argv)
    aplica = MainAplication()
    aplica.show()
    sys.exit(app.exec_())